Where they go: Human toxicokinetics and environmental fate

Objectives

• To provide the components of the GRACIOUS Framework and the associated ITS for substantiating grouping approaches, which support read-across and classification for NMs/NFs with regard to “Where they go”.
• To develop read-across hypotheses based on the GRACIOUS Framework and build the ITS to answer these hypotheses by using relevant existing tools (strategies, data, methods, models, etc.) for fate, uptake and toxicokinetics characterisation, to deliver data for regulatory registration and compliance, while enabling customisation for various stages of industrial innovation and Stage-Gate processes.
• To iteratively test the grouping and read-across hypotheses and associated ITS against relevant case studies (in collaboration with WP2) to identify needed improvements.
• To assess and where needed improve current components of the GRACIOUS Framework and existing tools for characterising fate, uptake and toxicokinetics, or where needed develop new tools or SOPs, to deliver essential information beyond current state-of-the-art Frameworks or tools for grouping and read-across.
• To provide a detailed description of the Framework components, tools and read-across options accompanied by user level guidance and assess their applicability for regulation and SbD.

Tasks

• Contribute to the overall grouping and read-across Framework design and its iterative refinement.
• Generate grouping and read-across hypotheses for different environments and uptake routes.
• Iteratively develop and test the GRACIOUS Framework, read-across hypotheses, associated tools and ITS on “where they go”.
• Identify and develop the means to address the needed improvements and missing information on “where they go” in the GRACIOUS Framework, and generate such information.
• Contribute to the Framework Guidance Document.

WP leader: Eric Bleeker, RIVM