The German Federal Institute for Risk Assessment (BfR) is the scientific body of the Federal Republic of Germany that prepares expert reports and opinions on issues related to food safety and consumer health protection (www.bfr.bund.de). The assessments are conducted according to internationally recognized scientific criteria. The institute provides sound scientific advice to federal ministries and agencies which are responsible for chemical safety, consumer protection and food safety. BfR also conducts own experimental research to strengthen and substantiate risk assessment processes. Due to its growing impact on the entire society BfR is currently investigating the impact of nanoparticles on human health in different projects and is also actively involved in method development for analytical and toxicological assessment of nanoparticles.